PharmOptima, LLC Since 2003, PharmOptima has been advancing drug discovery by providing  in vitro  and  in vivo  contract research services. PharmOptima’s  in vitro  expertise includes biochemistry, protein cloning and expression, cell-based assays, immunosorbent assays (traditional ELISA’s and electrochemiluminescent MSD formats) and biomarker research.  The Company’s  in vivo  research services include delivery, efficacy, tolerance, pharmacokinetics and ADME. PharmOptima, utilizing over 12,000 square feet of laboratory space including a 7000 square foot vivarium, is a premier provider of Spinal Muscular Atrophy research, in addition to being recognized as a leading CRO conducting ocular research. PharmOptima’s Core Expertise specialized ophthalmic services in vivo  ADME,  in vitro  ADME metabolite profiling & identification LC-MS/MS bioanalytical method development and validation pharmacology pharmacokinetic analysis transgenic Spinal Muscular Atrophy mouse Breeding Colony animal proof of concept testing experimental formulations for PK in vivo  delivery efficacy biomarker assay development immunogenicity testing drug-drug interactions ligand binding assays: ELISA, RIA