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Sourcing Inquiry Logo Microinnova Engineering GmbH

Microinnova Engineering GmbH

Regions
Europe, Asia
Countries
Austria, Israel
Size
20-50
Specialty
Service category
Pharmaceutical process development and validation, Others
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Key services

Services

 

 

Entry fine chemicals

Fine chemicals producing companies have an increased market pressure caused by new competitors. The pressure generates a need to increase the performance development and production processes and to reduce the costs. Labour costs are the main advantage of the new competitors. Automation is easy for continuous working processes using microstructures. Labour costs can be saved as well as the performance can be increase based on micro chemical engineering principles. Scale-up becomes easier, since there is no need for a large number of scaleup-experiments. Yields can be increased up to 40 %. New windows of operation have a significant impact on processing costs. The typical starting point is a basic feasibility study.


Entry Pharma

In the process development of a pharmaceutical active substance the development time forms a substantial success criterion. The time for tests can be lowered by the use of micro-process engineering development lab plants typically around 17% with halving the substance need simultaneously. Further saving capabilities are due to the automation of the laboratory plant as well as as a result of employment of on-line analytics. Within few hours a laboratory plant can be reequipped into a pilot plant. That is to say, the classical Kilo-laboratory is omitted. The quantities needed for toxicological tests can be, possibly somewhat modified, manufactured easily over the laboratory plant. For an cost-optimized production process all advantages of micro process engineering are then available. By the use of micro reactors the multi-level synthesis routes enable substantial yield increases, which are characterised by very short amortization periods in the order of magnitude of 2 to 3 years for instance. Plant components with high-grade toxic substances can be encased easily. The typical entrance is a basis feasibility study.


Process develompent

Microinnova optimizes processes by means of micro chemical engineering. Due to a enhanced mass- and energy transport process intensification is reached by use of microstructured devices. By the application of micro chemical engineering quality improvements and increased yield can be realized requiring low investment costs at the same time compared to conventional chemical engineering technology.


Production scale

Scale up Production plants feature higher flow rates than laboratory plants. In order to transfer processes from laboratory scale to production scale, the so called "scale-up" is used.


Other Services

  • Demonstrations
  • Training
  • Potential assassment Study

Microinnova optimizes processes by means of micro chemical engineering. Due to a enhanced mass- and energy transport process intensification is reached by use of microstructured devices. By the application of micro chemical engineering quality improvements and increased yield can be realized requiring low investment costs at the same time compared to conventional chemical engineering technology. The chemical process development takes place in continous working laboratory scale plants. Due to the early cooporation of chemists and chemical engineers a better part of the development can be carried out at laboratory scale. Thereby experiments on pilot scale can be reduced to a minimum, what leads to a quick and cost efficient process development and consecutive scale-up to the production scale. Microinnova offers basic feasability, technical feasability and industrial feasability studies, whereas process development is mainly applied to conversions in the pharmaceutical and fine chemical industry. Microinnova develops liquid-liquid, liquid-gas and gas-catalyst processes in microstructured devíces as well as emulsion- and precipitation processes and mulit phase reactions.
The chemical process development takes place in continous working laboratory scale plants. Due to the early cooporation of chemists and chemical engineers a better part of the development can be carried out at laboratory scale. Thereby experiments on pilot scale can be reduced to a minimum, what leads to a quick and cost efficient process development and consecutive scale-up to the production scale.
Microinnova offers basic feasability, technical feasability and industrial feasability studies, whereas process development is mainly applied to conversions in the pharmaceutical and fine chemical industry. Microinnova develops liquid-liquid, liquid-gas and gas-catalyst processes in microstructured devíces as well as emulsion- and precipitation processes and mulit phase reactions.

 

Process develompent

  • Catalyst screening
  • Basic feasibility study
  • Laboratory scale plants planning
  • Proof of process

The meaning of pilot plants for the proof of process is significantly shrinking by the adoption of microreaction technology. It is possible to test many process operations already in the labscale plant. A lot of data for the plant design can be obtained on labscale too. Tests on pilot plants can be considerably reduced or in special cases even fully omitted.


Basic Engineering

One of the principal purposes within the range engineering of the Microinnova engineering GmbH is to convert both internally and externally developed micro-process engineering processes into an application of productions. As a basis serve the process data compiled in the process development (Process development), which are adapted on the requirement of a production plant.
The issue of the basic engineering is to provide mass and energy balances, R&I patterns, the selection and dimensioning of the main equipment components as well as the investment and operating cost computations. For a well working production plant it is necessary to find above all the correct mixture between the new micro technology and the conventional equipment technology. The correct dimensioning of micro-structured apparatures is thereby one of our core competence.
Successfully accomplished production conversions confirm our commitment and encourage ourselves in our opinion that micro process engineering will take a more and more important role in a cost-saving future-oriented chemical production.


Plant "Scale up"

Scale up Production plants feature higher flow rates than laboratory plants. In order to transfer processes from laboratory scale to production scale, the so called "scale-up" is used. Microinnova , which regards the development of micro-process engineering plants as one of its core competences, occupies with the "scale-up" in R&D, and could conceive already success on the tons/hour scale (Production).
In order to accomplish the scale-up successfully, one has to take a look beside at the material system and the equipment components, as for example pumps and valves, at the principal item of one µVT - plant: the micro reactor. In order to obtain larger product streams with the same concentration as in laboratory or pilot plants, two principles can be used: (A) in the"numbering-up" several micro reactors are switched parallelly, (B) by means of the scale out (Technology), a micro reactor for the production scale is developed.


Other Services


Micro chemical engineering plant, demonstration und analytic

Microinnova owns various typs of plants with throughputs in the lab and pilot scale range. Plants for liquid-liquid, liquid-gas and catalysed gasphase processes are set-up with a wide range of microreactors and other microstructured devices in the lab or can be modified for it in a short period of time. Precipitation processes can be carried out as well photocatalysed processes. Further types of unit operations can be provided on request. Demonstation of the plants is possible by appointment.
Labfacilities of Microinnova provide usual instrumental analytic equipment like GC-MS (Varian), FT-IR (Biorad/Varian ) and UV-VIS_Spectrometer (Shimatzu) for process development projects. Titrations, pH-value, conductivity measurements and a lot more parameters are self-evident.
Estimating the potential
look at Basic feasability study
Studys
look at Basic feasability study
Laboratory Plant

We refer to labscale microreactor plants as continuous flow plants with microstructured devices that can adopt throughputs up to 200 ml/min of liquids or 2500ml/min of gases. ... more
Pilot Plant

A pilotscale microreactor plant is designed on the basis of an optimized labscale plant with about five to twenty times higher throughputs. It is usually used to support calculated scaling factors. ...more
Production Plant

Microreactors become more and more accepted as tools for chemical production. The fields of application are optimization of existing plants as well as new production plants. ...more
Devices

The engineering team of Microinnova works on the industrial implementation of microreactors. In principle there are two types of projects. The first type of project is a process intensification project.
... more
Analytics und Sensoric

On-line analytics and sensor technology are apart from the micro-process engineering components a very important component of micro-process engineering plants. ...more
Process Control

Hardware: For the collection and regulation of processes the Microinnova develops a special process rack. ... more

The software development at Microinnova is made on the basis of LabVIEW. Due to the high flexibility of the process control system there is no “uniform” appearance of the program. ...more
Periphery

Micro process engineering makes also special demands on the peripheral components. Microinnova has build up large know-how in the area of the selection of the suitable components by means of long lasting testing. ...more
Overall

We refer to labscale microreactor plants as continuous flow plants with microstructured devices that can adopt throughputs up to 200 ml/min of liquids or 2500ml/min of gases. Chemical and/or physical conversions can be made in such plants. They are mainly used as development tool for chemical development and process optimization, but are also employed for production of small amounts of high valuable products. This, ofcourse, requires that the plant is planned and constructed according to required regulatories from the beginning .
Customer orientation

The needs of the chemical systems of the customer define the design of our labscale plants. Usually the plant design is the result of a preceding basic feasibility study carried out in the laboratories at the Microinnova Engineering GmbH. In the first place such a study clears up if the chemical and/or physical problem is convertible to a continuous, microreaction plant and which are the best suited components. Usual demands to a microreactor plant are flexibility, expandability, scalability, automation, special chemical resistance and so on. The resulting labplant design can be adapted to fit to existing laboratory facilities of the customer. It is also possible to integrate parts of a lab plant to an existing continuous flow plant.
Meaurement and control technology

Labscale microreactor plants are controlled via MPDS programmed on the basis of LabView. This software can easily be adapted to different plants and changing designs in the development procedure. Pt-100 temperature sensors and piezo-resistive pressure sensors are integrated in the plant by default. More special sensors , such as pH, FT-NIR, elektrical conductivity and so on, can be installed if they are desired.
Microreactors and pumping concepts

The chemical and/or physical system and the way the customer wants to use the microreactor plant are the main arguments for reactor selection. The pumping concept depends directly on the used microreactor and the throughput as well as on the medium. Analytical HPLC pumps, micro annular gear pumps and centrifugal pumps are just three pumping concepts that can be used in microreactor plants.
General

A pilotscale microreactor plant is designed on the basis of an optimized labscale plant with about five to twenty times higher throughputs. It is usually used to support calculated scaling factors. On the other hand it can be used as small production system.
Pilotplants as small production systems

30.000 to 50.000 chemicals are produced and/or distributed in the European Community. One third of these chemicals are needed in amounts of less then ten tons. Espacially in this large segment microreaction technology can bring benefits with on demand concepts for fine chemicals production. the big advantage of microreaction technology is that the process design is already produced in the labscale phase in the chemical development. An optimized labscale laboratory method can usually be directly transfered into pilotscale. So it is possible to start a small scale production in a very short time after finishing the chemical development and make up to some hundreds kilogram of product available.
Microreactors become more and more accepted as tools for chemical production. The fields of application are optimization of existing plants as well as new production plants. Payback periods of less then a year are possible in projects due to yield and capacity increase. Furthermore microreaction technology is used for production processes where safety is an issue.
Microinnova Engineering GmbH is specialized on Micro Reaction Technology. The microreactor with the maybe largest throughput in production use has been started up in June 2005. The reactor rated by Microinnova has a capacity of 3 tons per hour. Microinnova Engineering GmbH offers services ranging from basic feasibility studies over pilot scale experiments to the production-implementation of chemical processes in microreactors.
Devices

Microinnova offers more than 30 different microstructured devices like microreactors or micro heat exchanger for lab, pilot and production scale.
Micro Chemical Engineering Components

Counter-Flow Micro Heat Exchanger
WT-Series

Tube Heat Transfer Micro Device
THTMD

Reactors

Falling Film Micro Reactor
FFMR

Micro Bubble Column
MBC

Gas Phase Micro Reactor
GPMR

Gas Phase Micro Reactor with Mixer and internal heating/cooling
GPMR-MIX

Catalyst Micro Burner Reactor
CMBR

Catalyst Testing Micro Reactor
CTMR

Mixer

Caterpillar Split-Recombine Micro Mixer
CPMM-V1.2 Group Class-R300, -R600, -R1200, - R2400

Star Laminator
Starlam Group Class -30, -300, -3000, -30000

Slit Interdigital Micro Mixer
SIMM Group Class SIMM-V2, HPIMM, SIMHEX, SSIMM

Liquid/Liquid Micro Mixer
LLMR-MIX

Superfocus Interdigital Micro Mixer
SFIMM-V2

Impinging-Jet Micro Mixer
IJMM



Distributor

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Analytics und Sensors

On-line analytics and sensor technology are apart from the micro-process engineering components a very important component of micro-process engineering plants. To use all advantages of micro process engineering the employment of suitable analytic devices, particularly on-line analytics and sensor technology, is essential. Thus a very high degree of automation is attainable, which results in further reduction of development times in the process development and even makes self-optimizing systems possible.

Analytical devices and sensor technology must be adapted on the small flow desired. The spectrum of the sensor technology ranges from simple systems for the determination of pressure, temperature and flow over pH probes to complex analytics methods, such as FT-NIR in special flow measuring cells.
Products

Process control


Hardware

For process control and data recording the Microinnova developed a special process rack. At the process interface measured values of pressure, temperature and flow sensors, as well as control factors and control variables are displayed on actuators such as pumps and valves. External I/Os, which are connected with a IPC by a data link, form the process interface. Our rack is conceived for universal wide range of applications.

© Copyright Microinnova
Software

The software development at Microinnova is made on the basis of LabVIEW. Due to the high flexibility of the process control system there is no “uniform” appearance of the program. It is custom-designed and adapted to each plant. We distinguish between the flexible Tool MPDS for the development with respect to the laboratory and the stable automation solution CA (Complete automation) for production plants.

The illustrated application above enables the measuring of 8 temperatures and 4 pressures. Furthermore, pumps and flows can be regulated. The visual representation of the signal process is realized by the merged diagrams. All process data are written when desired in an Excel table, whereby each signal process can be represented in the form of diagrams additionally too. Any inaccuracies of the sensor technology can be balanced by a calibration function easily and fast. There is also the possibility to integrate on-line analytics.
Products

Periphery

Micro process engineering makes also special demands on the peripheral components. Microinnova has build up large know-how in the area of the selection of the suitable components by means of long lasting testing.

Among important peripheral components rank:

• Pumps and/or promotion concepts

• Filter systems

• Armatures

• Connection technique

• Safety engineering

The products must be adapted individually to the process and plant. The criteria for choice are basic conditions, which result from the plant and/or the micro technology, as well as chemical stability, pressure and temperature stability or ability for cleaning, to mention some of many criteria.

 

Approvals, Certificates, Authorisations

  • cGMP

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