- North America
- United States
- Service category
- Pre-clinical development and testing, pre-clinical CRO, Analytical laboratory and testing services
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Sigmovir Biosystems, Inc. (SBI) is a Maryland-based biotechnology company specializing in the cotton rat model of human infectious diseases. Species of the cotton rat (genus Sigmodon) have been shown to be permissive for a wide array of human viral, bacterial, and parasitic pathogens. For the majority of these infectious agents, the cotton rat represents a more reliable model of human disease than the common murine strains and other small animal models. RSV, hPIV, Influenza, and HSV are among the best examples in this group. The validity of the model is best illustrated by the fact that prophylactic antibody treatment against severe RSV disease in infants advanced to clinical trials based on studies conducted in cotton rats alone, without the need for an additional testing in primates.
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