Description

We are looking for a CRO (worldwide) that routinely runs stimulus-induced release of cytokines (e.g. IL-6, Il-8, IL1b, TNF) from corneal epithelial cells (e.g. hyperosmolarity-induced cytokine release). We aim to test the modulatory effect on the stimulus-induced cytokine release of a number of test items.
Cells of human origin are preferred but we also consider the use of cells from other species, i.e. rat, mouse. Both, the use of cells lines as well of primary isolated cells is acceptable.
Please state whether basic data (concentration and time dependencies) can be provided in order to prove that the model system is working. A positive control demonstrating Inhibition of cytokine release should be already available.