Looking for CRO with B-cell chronic lymphocytic leukemia model
We are developing novel drugs against autoimmune and oncologic diseases. Currently we are looking for a CRO, which has solid expertise in conducting efficacy tests in rodents. We are planning the studies with following experimental model:
∙ B-cell chronic lymphocytic leukemia - e.g. Eμ-miR-29 transgenic mice.
We plan to apply the following design:
1. Negative control - pathology + vehicle.
2. Positive control - pathology + standard of care.
3. Pathology + test compound 1-st dose i/p (4 times, once weekly).
4. Pathology + test compound 2-nd dose i/p (4 times, once weekly).
5. Pathology + test compound 3-rd dose i/p (4 times, once weekly).
6. Pathology + test compound 4-th dose i/p (4 times, once weekly)
7. *-i/p - intraperitoneally.
8. Total number of animals = 90 (15 mice per group).
We would like to receive a preliminary quotation and determination of time.
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