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Looking for Provider/Consultant to perform PK/PD Modelling/Simulation

  • Pre-clinical development and testing, pre-clinical CRO, Clinical development and testing, clinical CRO, Consulting - strategy and development, Others
  • Human Medicines, Biopharmaceuticals
  • Europe
  • 12/26/2014


The task is to simulate the pharmacokinetic profile of antibodies and other macromolecules in combination with their respective soluble ligands (free and bound). Parameters of interest are for example the concentrations of free and bound macromolecule and target after single and multiple dosing. Plasma concentration profiles are available for both total drug and target (no experimental differentiation between free and bound) from single dose applications after iv and sc administration in Phase I/II clinical studies. Additional preclinical data from distribution and excretion studies can be provided and should be considered to support the model. The service provider should have experience with the the pharmacokinetics and binding specifics of macromolecules. Provider from Europe preferred.

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