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Modell to investigate the antiinflammatory activity of test items which have pyrogenic activities by itself

  • Pre-clinical development and testing, pre-clinical CRO
  • Human Medicines
  • Europe
  • 08/11/2012

Description

To determine the antiinflammatroy activity of our test items we need an in vitro cell assay which allows the measurment of an inflammatory response from immun cells (e.g. cytokine or PGE2 release from macropahges, neutrophils?). The problem is that some of our items have some LPS contaminations. We therefore need an assay system which allows immunological stimulation but is insensitive to LPS.

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