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PK Study in Cynomolgus - In-Life

  • Pre-clinical development and testing, pre-clinical CRO
  • Biopharmaceuticals
  • Europe, North America
  • 06/20/2012

Description

Looking for a provider to conduct an intravenous PK Study in Cynomolgus. Cynomolgus are not required to be drug-naïve. Test material at three doses can be applied either as single dose to separate Cynomolgus in groups of 2 males / 2 females (total of 3 x 4 = 12 Cynomolgus) or dose-escalating in same Cynomolgus (total of 4 Cynomolgus) separated by a period of 2 weeks. Decision will be based on cost. For each dose group there will be a total of 11 PK sampling points until 168 h post-dose. Three aliquots of 150 µl platelet-poor plasma will be required from each PK sample taken. Optional: (A) white blood cell count and if possible CD34+ cell count at all PK sampling points, (B) 24 h urine collection (0 to 24 h post-dose, only, total of 12 samples). There will be one sample shipment on dry ice at the end of the study.

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